2. Signaling Pathways
  3. GPCR/G Protein
    Neuronal Signaling
  4. Cannabinoid Receptor

Cannabinoid Receptor

Cannabinoid Receptor

Cannabinoid Receptor

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Cannabinoid receptors are currently classified into three groups: central (CB1), peripheral (CB2) and GPR55, all of which are G-protein-coupled. CB1 receptors are primarily located at central and peripheral nerve terminals. CB2 receptors are predominantly expressed in non-neuronal tissues, particularly immune cells, where they modulate cytokine release and cell migration. Recent reports have suggested that CB2 receptors may also be expressed in the CNS. GPR55 receptors are non-CB1/CB2 receptors that exhibit affinity for endogenous, plant and synthetic cannabinoids. Endogenous ligands for cannabinoid receptors have been discovered, including anandamide and 2-arachidonylglycerol.

Cannabinoid Receptor Isoform Specific Products:

Cannabinoid Receptor Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-10013A
    Taranabant racemate
    		Antagonist 99.82%
    Taranabant racemate (MK-0364 racemate) is an antagonist and/or inverse agonist of the Cannabinoid-1 (CB1) receptor extracted from patent WO 2004048317 A1.
    Taranabant racemate
  • HY-P1090
    Hemopressin(rat)
    		Antagonist 99.86%
    Hemopressin(rat) is a nonapeptide derived from the α1-chain of hemoglobin, is originally isolated from rat brain homogenates. Hemopressin(rat) is orally active, selective and inverse agonist of CB1 cannabinoid receptors. Hemopressin(rat) exerts antinociceptive action in inflammatory pain models.
    Hemopressin(rat)
  • HY-103325
    JTE-907
    		Inhibitor 98.54%
    JTE-907 is a selective and orally active cannabinoid CB2 receptor inverse agonist and exerts anti-inflammatory effects. JTE-907 upregulates IL-6, MCP-1, IL-1β, VEGF, ANGPTL4, and TRPV1 in mature adipocytes. JTE-907 downregulates CB1, MCP-1, and IL-1β in preadipocytes. JTE-907 inhibits ear swelling in mice. JTE-907 reverses the protective effects of CB2 agonists and Anandamide (HY-10863) against cytokine-evoked colonic mucosal damage. JTE-907 can be used for the research of allergic dermatitis, obesity, and colitis.
    JTE-907
  • HY-122964
    URB447
    		Antagonist 99.5%
    URB447 is a peripherally restricted CB1 cannabinoid antagonist (IC50: 313 nM and 41 nM for rat CB1 and human CB2 receptor respectively ). URB447 lowers food intake and body-weight gain in mice without entering the brain or antagonizing central CB1-dependent responses. URB447 can be used for research of obesity.
    URB447
  • HY-W013788
    2-Palmitoylglycerol
    		Agonist 99.0%
    2-Palmitoylglycerol (2-Palm-Gl), an congener of 2-arachidonoylglycerol (2-AG), is a modest cannabinoid receptor CB1 agonist. 2-Palmitoylglycerol also may be an endogenous ligand for GPR119.
    2-Palmitoylglycerol
  • HY-121541
    CB-25
    		98.84%
    CB-25 is a ligand of CB1 cannabinoid receptors, acting as a partial agonist. CB-25 enhances Forskolin (HY-15371)-induced cAMP formation in cancer cells but not hCB1-CHO cells.
    CB-25
  • HY-172587
    CB1R Allosteric modulator 5
    		Modulator 98.35%
    CB1R Allosteric modulator 5 (compound 3) is a selective, and blood-brain barrier (BBB) permeable Cannabinoid receptor type 1 allosteric modulator with a pIC50 of 6.89. CB1R Allosteric modulator 5 attenuates both cocaine-seeking behavior specific to cue-induced reinstatement and cocaine-induced behavioral sensitization without altering locomotor activity.
    CB1R Allosteric modulator 5
  • HY-W775306
    Cannabidivarinic acid
    		Ligand 99.67%
    Cannabidivarinic acid (CBDVA), the carboxylic acid precursor of Cannabidivarin(CBDV), is a non-psychoactive cannabinoid found in Cannabis with anti-inflammatory properties.
    Cannabidivarinic acid
  • HY-W036121
    (1H-Indol-3-yl)(2,2,3,3-tetramethylcyclopropyl)methanone
    		99.99%
    (1H-Indol-3-yl)(2,2,3,3-tetramethylcyclopropyl)methanone (UR-144 Impurity 3) is a precursor in the synthesis of synthetic cannabinoids.
    (1H-Indol-3-yl)(2,2,3,3-tetramethylcyclopropyl)methanone
  • HY-113421S
    Linoleoyl ethanolamide-d4
    		99.2%
    Linoleoyl ethanolamide-d4 is a deuterated labeled Linoleoyl ethanolamide. Linoleoyl ethanolamide (Linoleic acid monoethanolamide) is classified as a fatty acid ethanolamide. Linoleoyl ethanolamide only weakly binds G-protein-coupled cannabinoid receptors of type-1（CB1）and CB2 receptors, and inhibits the binding of [3H]CP-55,940 with Kis of 10 and 25 μM, respectively. Linoleoyl ethanolamide is 4-fold less potent than anandamide at causing catalepsy in mice and it does not prolong sleep time.
    Linoleoyl ethanolamide-d<sub>4</sub>
  • HY-118641
    Cannabinodiol
    		99.90%
    Cannabinodiol, a cannabinoid analogue, is a phytocannabinoid.
    Cannabinodiol
  • HY-12761
    A-836339
    		Agonist 99.84%
    A-836339 is a selective CB2 receptor agonist, with Ki values of 0.4 nM and 0.8 nM in humans and rats, respectively. A-836339 exhibits multiple effects such as analgesia, gastric protection, anti-inflammation, and antioxidant activity. A-836339 produces antinociceptive and analgesic activities by activating CB2 receptors in the dorsal root ganglia and spinal cord. A-836339 can also exert gastric protective effects through anti-inflammatory mechanisms (reducing TNF-α and IL-1β) and antioxidant mechanisms (enhancing the activities of CAT and SOD, and reducing H2O2). Radioactively labeled A-836339 can serve as a CB2-specific radioligand for autoradiography and PET imaging. A-836339 can be used in research on inflammatory pain, neuropathic pain, gastric ulcers, cerebral ischemia, etc.
    A-836339
  • HY-148176
    ANEB-001
    		Inhibitor 99.73%
    ANEB-001 is an orally active CB1 inhibitor, can be used to research acute cannabinoid intoxication.
    ANEB-001
  • HY-110189S1
    Pregnenolone monosulfate-d4 sodium
    		Inhibitor 99.8%
    Pregnenolone monosulfate-d4 sodium is the deuterium labeled Pregnenolone monosulfate sodium (HY-110189) . Pregnenolone monosulfate sodium (3β-Hydroxy-5-pregnen-20-one monosulfate sodium) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone monosulfate sodium acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone monosulfate sodium can protect the brain from cannabis intoxication. Pregnenolone monosulfate sodium is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels.
    Pregnenolone monosulfate-d<sub>4</sub> sodium
  • HY-124283A
    LEI-101
    		Agonist 99.35%
    LEI-101 is a potent, selective, and orally bioavailable cannabinoid CB2 receptor agonist, with a pEC50 of 8 for hCB2, and a pKi of less than 4 for hERG. LEI-101 is ~100-fold more potent in binding to CB2 receptors than to CB1 receptors.
    LEI-101
  • HY-148940
    Docosahexaenoyl glycerol
    		≥99.0%
    Docosahexaenoyl glycerol is an analog of endocannabinoid, which stimulates the glucose uptake and exhibits anti-inflammatory efficacy.
    Docosahexaenoyl glycerol
  • HY-132217
    CB2 receptor agonist 2
    		Agonist 99.9%
    CB2 receptor agonist 2 is a potent and selective agonist for the CB2 (cannabinoid type 2) receptor with a Ki of 8.5 nM. CB2 receptor agonist 2 has high affinity and selectivity for CB2.
    CB2 receptor agonist 2
  • HY-125111
    PSB-SB-487
    		Modulator 98.01%
    PSB-SB-487 is a potent GPR55 antagonist and CB2 agonist with an IC50 value of 0.113 µM for GPR55, and a Ki value of 0.292 µM for human CB2. PSB-SB-487 can be used for researching diabetes, Parkinson’s disease, neuropathic pain, and cancer.
    PSB-SB-487
  • HY-B0151S
    Pregnenolone-d4
    		Inhibitor
    Pregnenolone-d4 is the deuterium labeled Pregnenolone. Pregnenolone (3β-Hydroxy-5-pregnen-20-one) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone can protect the brain from cannabis intoxication. Pregnenolone is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels.
    Pregnenolone-d<sub>4</sub>
  • HY-113591
    CB2 receptor agonist 10
    		Activator 99.9%
    CB2 receptor agonist 10 is a CB2 receptor agonist with a Ki of 3.7 nM for hCB2, a Ki of 110 nM for hCB1, and an EC50 of 0.52 nM for hCB2.
    CB2 receptor agonist 10
Cat. No. Product Name / Synonyms Application Reactivity
Cannabinoid Receptor Isoform Comparison

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